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If time interval amongst injections is bigger than thirteen months, pregnancy should be excluded prior to administering the drug.
The Women of all ages's Overall health Initiative investigated the use of a combination of oral CEEs and MPA compared to placebo. The review was prematurely terminated when previously unforeseen risks ended up discovered, specially the discovering that however the all-cause mortality was not afflicted from the hormone therapy, the many benefits of menopausal hormone therapy (decreased possibility of hip fracture, colorectal and endometrial most cancers and all other leads to of Demise) were offset by improved possibility of coronary heart disease, breast cancer, strokes and pulmonary embolism.[90]